For a client taking isoniazid, which of the following should be monitored as a potential side effect?

Isoniazid is an antibiotic commonly prescribed for the treatment of tuberculosis. One important aspect of isoniazid therapy is the potential for peripheral neuropathy, especially in patients who may be predisposed to this condition, such as those with vitamin B6 deficiency, diabetes, or excessive alcohol use. Isoniazid can interfere with the metabolism of pyridoxine (vitamin B6), leading to decreased levels of this vitamin, which is critical for maintaining proper nerve function. Symptoms of peripheral neuropathy can include numbness, tingling, and pain in the hands and feet.

Monitoring for peripheral neuropathy is essential in patients taking isoniazid to ensure early detection and intervention, which may include the administration of vitamin B6 supplements to prevent or mitigate this side effect. As a result, healthcare providers must be vigilant in assessing patients for signs and symptoms of peripheral neuropathy throughout the course of treatment with isoniazid.