What class of drugs does Lisinopril belong to?

Study for the UWorld Pharmacology Test. Use flashcards and multiple choice questions, each with hints and explanations. Get ready for your exam!

Lisinopril belongs to the class of medications known as ACE inhibitors. ACE stands for angiotensin-converting enzyme, which is crucial in the body's renin-angiotensin-aldosterone system (RAAS). This system regulates blood pressure and fluid balance. By inhibiting the action of the ACE, lisinopril prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This reduction in angiotensin II levels leads to vasodilation, decreased blood pressure, and reduced strain on the heart.

ACE inhibitors like lisinopril are commonly prescribed for the management of hypertension, heart failure, and certain types of kidney disease. They are effective in preventing complications related to hypertension, such as heart attack and stroke, by promoting smoother blood flow and decreasing the workload of the heart.

In contrast, beta-blockers target the beta-adrenergic receptors to reduce heart rate and myocardial contractility; calcium channel blockers inhibit calcium entry into cells to relax vascular smooth muscle; and thiazide diuretics promote diuresis by inhibiting sodium reabsorption in the kidneys. Each of these classes works differently than ACE inhibitors in managing cardiovascular conditions.

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