What condition may arise from the overuse of NSAIDs?

The overuse of nonsteroidal anti-inflammatory drugs (NSAIDs) is well-known to be associated with kidney damage. NSAIDs can interfere with the normal function of the kidneys by inhibiting the production of prostaglandins, which are important for maintaining blood flow to the kidneys and regulating glomerular filtration rate. When prostaglandins are inhibited, particularly in individuals who are already predisposed to kidney issues or in situations where renal blood flow is compromised (such as dehydration), it can lead to acute kidney injury or chronic kidney disease over time.

Additionally, excessive use of NSAIDs can exacerbate underlying conditions such as hypertension or heart failure, further increasing the risk of renal harm. Monitoring kidney function is crucial for patients who are on long-term NSAIDs, highlighting the importance of this connection in clinical practice.