What is a common effect of desmopressin therapy in a patient with diabetes insipidus?

Study for the UWorld Pharmacology Test. Use flashcards and multiple choice questions, each with hints and explanations. Get ready for your exam!

Desmopressin is a synthetic analogue of vasopressin, also known as antidiuretic hormone (ADH). In patients with diabetes insipidus, which is characterized by the inability to concentrate urine due to insufficient levels of ADH, the administration of desmopressin helps to treat this condition effectively.

When desmopressin is administered, it enhances water reabsorption in the kidneys, particularly in the collecting ducts. This results in a notable decrease in urine output. The kidneys become more efficient at retaining water, leading to concentrated urine and a reduction in the volume of urine produced. Consequently, patients often experience less frequent urination, and the overall urine output decreases significantly.

In this context, the correct answer reflects the pharmacological action of desmopressin, making it a suitable treatment option for individuals with diabetes insipidus to manage their symptoms effectively.

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