Which client statement regarding methotrexate for rheumatoid arthritis is most concerning?

Study for the UWorld Pharmacology Test. Use flashcards and multiple choice questions, each with hints and explanations. Get ready for your exam!

The statement expressing concern about having small, purple spots all over the skin is particularly important when considering the use of methotrexate for rheumatoid arthritis. Methotrexate is an immunosuppressant commonly used to manage autoimmune diseases, including rheumatoid arthritis. One of its potential side effects is the risk of cytopenias, such as thrombocytopenia, which can lead to the formation of petechiae—small, purple spots caused by bleeding under the skin. This symptom can indicate a serious side effect of the medication, suggesting that the client may be at risk for bleeding complications.

While the other statements may highlight issues such as gastrointestinal side effects or lifestyle choices (like caffeine consumption and birth control), they do not reflect immediate or severe complications associated with methotrexate therapy. Vomiting can be a side effect but may not indicate a serious health risk. Similarly, caffeine intake is not directly related to methotrexate's action or its complications, and the decision to stop birth control could be concerning but does not present an acute risk to the patient’s health or treatment efficacy. Thus, the presence of small, purple spots represents a more urgent situation that requires further investigation and possibly intervention.

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