Which instruction should be included for a client prescribed isoniazid (INH) for latent tuberculosis?

Isoniazid (INH) is an antibiotic commonly prescribed for latent tuberculosis. One important instruction for clients taking this medication is to avoid drinking alcohol. This caution is critical because combining isoniazid with alcohol can increase the risk of liver toxicity. Isoniazid itself is metabolized in the liver, and alcohol can exacerbate the strain on liver function, potentially leading to hepatitis or other hepatic issues. Therefore, advising the patient to abstain from alcohol helps reduce the chances of hepatotoxic effects and ensures safer management of their therapy.

It's also essential for patients to be aware of the other symptoms associated with isoniazid use, such as reporting yellowing of the skin or eyes, as this could signal liver problems. However, monitoring liver function and avoiding alcohol is a primary preventive measure that is crucial in the context of isoniazid treatment.