Which medication can reverse the effects of benzodiazepines?

Study for the UWorld Pharmacology Test. Use flashcards and multiple choice questions, each with hints and explanations. Get ready for your exam!

Flumazenil is a specific antagonist for benzodiazepines and is used in clinical settings to reverse the sedative effects when there is an overdose or prolonged sedation. It works by competitively inhibiting the action of benzodiazepines at their binding sites on the GABA-A receptor, effectively reversing their effects on the central nervous system. This is particularly useful because its action can help restore consciousness and improve respiratory function in patients who have been sedated excessively by benzodiazepines.

Other medications listed do not counteract the effects of benzodiazepines: Atropine is an anticholinergic agent used for various conditions like bradycardia but doesn't affect benzodiazepine activity. Naloxone is an opioid antagonist used to reverse opioid overdose and has no impact on benzodiazepine effects. Propranolol is a non-selective beta-blocker used for hypertension and anxiety but again does not reverse benzodiazepine effects. Thus, flumazenil is the appropriate choice for reversing benzodiazepine sedation.

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