Which medication is most likely causing sinus bradycardia in a client with type 2 diabetes and heart failure?

Study for the UWorld Pharmacology Test. Use flashcards and multiple choice questions, each with hints and explanations. Get ready for your exam!

Carvedilol is a non-selective beta-blocker that is commonly used in the management of heart failure and can also play a role in decreasing heart rate and contractility. In patients with heart failure, especially those who are also diabetic, carvedilol can be beneficial for improving cardiac function and reducing mortality. However, one of the side effects of beta-blockers, including carvedilol, is the potential to cause sinus bradycardia, which is characterized by a heart rate that is less than 60 beats per minute.

In this scenario, the presence of sinus bradycardia in a patient taking carvedilol is not uncommon, as the medication works by blocking the effects of adrenaline on the heart, leading to a decrease in heart rate. This is particularly important to note for healthcare providers, as it emphasizes the need for regular monitoring of heart rate in patients receiving beta-blocker therapy.

The other medications listed—captopril, glimepiride, and levothyroxine—do not typically have sinus bradycardia as a significant side effect. Captopril is an ACE inhibitor used for hypertension and heart failure management, glimepiride is a sulfonylurea for controlling blood sugar levels in diabetes

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