Which medication should be avoided in a client taking clopidogrel?

The medication that should be avoided in a client taking clopidogrel is ibuprofen for its anti-inflammatory effects. Clopidogrel is an antiplatelet agent that helps prevent blood clots by inhibiting platelet aggregation. When used alongside nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, there is an increased risk of gastrointestinal bleeding. Both clopidogrel and ibuprofen can affect platelet function and gastrointestinal integrity, which can enhance the risk of adverse effects, particularly in patients who may have other risk factors for bleeding or who are already on anticoagulation therapy.

Using aspirin for pain relief is sometimes acceptable when properly managed because it is also an antiplatelet, but doctors may consider it depending on the patient's specific situation. Antacids for heartburn generally do not interact adversely with clopidogrel, making them a safer option, and digoxin does not have a significant interaction with clopidogrel, so it can be used in patients who require cardiac treatment. Hence, ibuprofen's potential to heighten bleeding risk makes it the medication to avoid in patients taking clopidogrel.